Install the extension via the Extension Manager. After installation you can configure the lifetime of the cache in the Extension Manager which defines how often a request will be made to the Twitter API.
Then you need to make a Twitter App: go to dev.twitter.com, login with your Twitter credentials and click the button Create a new application. Fill in the mandatory details and submit. On the next page the details of your just-created App are shown and now you need to click Create my access token. After that you have all the details you need.
When you have the Twitter App details, install the static template of Twitter Feed. Edit the constants and replace the values of plugin.tx_cwtwitter.settings.oauth with the corresponding values of the Twitter App.